PROTECTIVE EFFECT OF ROSMARINUS OFFICINALIS EXTRACT ON THE NEPHROTOXICITY CAUSED BY NICKEL CHLORIDE IN WISTAR RATS

Nickel is a common environmental pollutant inducing nephrotoxicity. Oxidative stress has been proposed as possible mechanism involved in this toxicity. The present study aimed to elucidate the potential protective effect of methanolic extract Rosmarinus officinalis (RO) against nephrotoxicity induced by Chloride (NiCl2). antioxidant activity and metal chelating power plant were evaluated. An vivo on 28 rats divided into equal four groups including first group control; second received 100 mg/kg bw RO extract; third was exposed 10 NiCl2, last treated with combination NiCl2 gavage for days. parameters, biochemical biomarkers, histopathological examination kidney determined. Analysis results showed that significant metal-chelating power. In addition, exposure caused disturbance renal function (urea, creatinine, uric acid). This also oxidative stress, which increased MDA level GST decrease status (CAT, GPx, SOD activity), alteration tissue architecture observed. Co-administration (extract NiCl2) restored most parameters cited above values close normal. Therefore, revealed ability bind protect from NiCl2-induced damage.